By P. Illes, H. Zimmermann
The learn of purinergic mechanisms has for lengthy been serious about the activities of the nucleoside adenosine, wherein the contribution of nucleotides to the signaling structures has been underestimated. in accordance with the complaints of a IUPHAR satellite tv for pc convention held in Leipzig, Germany, this ebook bargains a complete replace and assessment of nucleotide unlock, the constitution and serve as of nucleotide receptors, nucleotide-metabolizing ecto-enzymes in addition to the physiological features of nucleotides within the frightened approach. The body structure and molecular biology of receptors for ATP and different nucleotides are tested, as are the body structure and molecular biology of enzymes that hydrolyze extracellular nucleotides. at this time, a pharmacology of the nucleotide signaling procedure is being constructed. Of specific curiosity is the construction of receptor subtype-specific antagonists and of substances that selectively have an effect on the extracellular life of the nucleotide. an outstanding resource of reference for institutes of pharmacology, biochemistry, neurology, zoology, and body structure, and for the pharmaceutical undefined.
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The research of purinergic mechanisms has for lengthy been involved in the activities of the nucleoside adenosine, wherein the contribution of nucleotides to the signaling structures has been underestimated. in keeping with the complaints of a IUPHAR satellite tv for pc convention held in Leipzig, Germany, this booklet deals a complete replace and evaluate of nucleotide liberate, the constitution and serve as of nucleotide receptors, nucleotide-metabolizing ecto-enzymes in addition to the physiological features of nucleotides within the apprehensive process.
Additional resources for Nucleotides and their Receptors in the Nervous System
C. K. (1997) Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. J. B i d . , 272: 24348-24354. P. and Cachet, C. (1997) The P2Y, receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. , 403: 26-30. K. A. (1997) The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses receptor. Biochem. Biophys. Res. , 236: 455-460.
1998a). - Dual signal transduction mechanisms Where a second messenger coupling has been identified for recombinant P2Y receptors, this has been the formation of IP,. However, in two recent cases two pathways for one receptor have been reported. , 1997). , 1997, 1998). More information on the mechanism of activation of these dual systems is required, in order to relate them to the G proteins proposed to be coupled to other P2Y receptors. 26 How many more P2Y receptor subtypes remain to be cloned?
1994) Ectoenzymes and metabolism of extracellular ATP. Drug Dev. , 32: 134-146. Zimmerman, H. (1996) Biochemistry, localisation and functional roles of ecto-nucleotidases in the nervous system. , 49: 589418. SECTION I1 Molecular biology of P2Y receptors This Page Intentionally Left Blank P. Illes and H. ) Progress in Brain Research, Vol 120 0 1999 Elsevier Science BV. E. A. Barnards Molecular Neurobiology Unit, Royal Free Hospital School of Medicine, Rowland Hill Street, Hampsfead, London NW3 2PE UK Present address: 'Department of Cell Physiology and Pharmacology, Universiv of Leicester; University Road, RO.
Nucleotides and their Receptors in the Nervous System by P. Illes, H. Zimmermann