New PDF release: Development and Application of Biomarkers (Protein Science)

By Roger L. Lundblad

ISBN-10: 1439819793

ISBN-13: 9781439819791

A accomplished overview of using biomarkers in diagnostics and prognostics, this ebook covers the heritage and present software of biomarkers, explores the know-how used for the validation and learn of biomarkers, and compares a number of the applied sciences used to spot and degree biomarkers. It investigates the evolution of the underlying know-how and discusses the interpretation of simple technology to medical laboratory use and power advertisement purposes. He additionally covers proteomics and proteomic applied sciences and their purposes within the identity of biomarkers.

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Yerra, L. , Human endothelium as a source of multifunctional cytokines: Molecular regulation and possible role in human disease, J. Interferon Cytokine Res. 19, 91–104, 1999) and other cells (Chudek, J. , Adipose tissue, inflammation and endothelial dysfunction, Pharmacol. Rep. , Interleukin-6: A regulator of plasma protein gene expression in hepatic and non-hepatic tissues, Mol. Biol. Med. , Inflammation, thrombosis and acute coronary syndromes, Diab. Vasc. Dis. Res. 2, 113–121, 2005). , Ultrarapid, ultrasensitive one-step kinetic immunoassay for C-reactive protein (CRP) in whole blood samples: Measurement of the entire CRP concentration range with a single sample dilution, Clin.

171, 1647–1651, 2003). , Mentlein, R. , The transmembrane CXC-chemokine ligand 16 is induced by IFN-γ and TNF-α and shed by the activity of the disintegrin-like metalloproteinase ADAM10, J. Immunol. 172, 6362–6372, 2004; Ludwig, A. , Transmembrane chemokines: Versatile ‘special agents’ in vascular inflammation, Thromb. Haemost. 97, 694–703, 2007). , Ueland, T. , Soluble CXCL16 predicts long-term mortality in acute coronary syndrome, Circulation 119, 3181–3188, 2009). K. , CD163: A regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response Ann.

The concept of molecular phenotyping on individual levels, in response to pharmacological intervention, provide the opportunity of clinical trials with n=1 ACE (angiotensin-converting enzyme) phenotyping may be more useful than ACE genotyping as an approach to personalized medicine for ACE inhibitors Use of transcriptional analysis (mRNA analysis via microarray technology) as an approach to the development of a molecular profile (biomarker) for personalized medicine Use of magnetic resonance imaging for identifying biomarkers for late-life depression as an approach to personalized medicine Use of single nucleotide polymorphisms for genotyping in developing a personalized medicine approach to acute macular degeneration The use of targeted imaging uses a radiolabeled probe that binds to specific structural component critical to a single disease or to a more general physiological response, such as inflammation in personalized medicine Current use of chromosomal profile to guide chemotherapy in malignant gliomas is an example of personalized medicine.

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Development and Application of Biomarkers (Protein Science) by Roger L. Lundblad

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