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By Alain A. Vertès, Masayuki Inui, Hideaki Yukawa (auth.), Hideaki Yukawa, Masayuki Inui (eds.)

ISBN-10: 3642298567

ISBN-13: 9783642298561

ISBN-10: 3642298575

ISBN-13: 9783642298578

Corynebacterium glutamicum was chanced on in Japan in 1956 as a common glutamate manufacturer. Its “microbial manufacturing facility” features, akin to its physiological plasticity and powerful catalytic functionalities, have considering the fact that facilitated the advance of effective construction procedures for amino acids, nucleotides and supplementations.

This monograph illustrates how the data gleaned from whole genome sequencing permits the rational engineering of the total mobile metabolism and the way platforms biology allows the additional optimization of C. glutamicum as a biocatalyst. points of gene legislation, metabolic pathways, sugar uptake, protein secretion, phone department and biorefinery purposes spotlight the large biotechnological and biorefinery capability.

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2007; Haussmann et al. 2009). Another interesting use of C. glutamicum for bioremediation or mining purposes is to cost-effectively recover by biosorption either toxic heavy metals such as lead and cadmium using corynebacterial biomass waste from lysine fermentation plants (Choi and Yun 2004) or high value metals such as gold, silver, platinum, or palladium (Das 2010; Kwak and Yun 2010; Sneha et al. 2010). Notably, corynebacterial biomass waste could also be successfully applied to the removal of dyes as exemplified by the biosorption of Reactive Black 5 or Reactive Orange 16, further extending the number of valorization options for corynebacterial biorefinery effluent wastes (Won et al.

Moreover, the development of dual stage processes enables critical cost efficiencies, whereby biomass production and product production phases are separated via a simple transition from aerobic metabolism to anaerobic metabolism in the absence of a main terminal electron acceptor and mediated by a simple manufacturing operation such as stopping aeration of the reacting corynebacterial culture (Inui et al. 2004b, 2010). 6 g/l (90 mM) (Litsanov et al. 2012). Furthermore, the ability to use anaerobic metabolism enables to cost efficiently produce relatively reduced substances (Marquardt et al.

Wiley, Chichester, pp 312–330 Isenberg JI, Maxwell V (1978) Intravenous infusion of amino acids stimulates gastric acid secretion in man. N Engl J Med 298:27–29 J€ager W, Peters-Wendisch PG, Kalinowski J, P€ uhler A (1996) A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins. Arch Microbiol 166:76–82 Jenke-Kodama H, Dittmann E (2009) Evolution of metabolic diversity: insights from microbial polyketide synthases. Phytochemistry 70:1858–1866 Jia X, Liu P, Li S, Li S, Wen J (2011) D-lactic acid production by a genetically engineered strain Corynebacterium glutamicum.

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Corynebacterium glutamicum: Biology and Biotechnology by Alain A. Vertès, Masayuki Inui, Hideaki Yukawa (auth.), Hideaki Yukawa, Masayuki Inui (eds.)

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