Download e-book for iPad: Ciba Foundation Symposium 169 - Aluminium in Biology and by

ISBN-10: 0470514302

ISBN-13: 9780470514306

ISBN-10: 0471934135

ISBN-13: 9780471934134

Favourite participants handle concerns in regards to the toxicity of aluminum which explanations an encephalopathy in renal dialysis sufferers and can also be recognized to wreck animals and crops through acid rain. Examines the chemistry and biology of aluminum compounds targeting the proof for and opposed to aluminum's position in Alzheimer's illness.


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It is mobilized from some store, presumably on tissue destruction (Davenport et a1 1988). Greger: We have preliminary data along that line too. We were studying ageing rats. We assumed that if we fed the rats 1 mg Al/g diet for as long as nine months, they would accumulate ever-increasing amounts of Al, especially in bone; but it wasn’t so. The A1 content of bone went up to a certain level and then levelled off; then soft tissue levels of A1 increased. We measured hydroxyproline excretion as an index of bone turnover.

Food Addit Contam 7:275-282 Dayde S, Filella M, Berthon G 1990 Aluminum speciation studies in biological fluids, part 3. Quantitative investigation of aluminum-phosphate complexes and assignment of their potential significance in vivo. J Inorg Biochem 38:241-259 Ecelbarger CA, Greger J L 1991 Dietary citrate and kidney function affect aluminum, zinc and iron utilization in rats. J Nutr 121:1755-1762 Eden T 1976 Tea. Longman, London, p 8-15 (chapter on climate and soils) Ellen G, Egmond E, Van Loon JW, Sahertian ET, Tolsma K 1990 Dietary intakes of some essential and non-essential trace elements, nitrate, nitrite and N-nitrosamines, by Dutch adults: estimated via a 24-hour duplicate portion study.

Lione (1985) estimated that 126-728 mg and 840-5000 mg were possible daily doses of aluminium in buffered analgesics and antacids, respectively. Aluminium-containing phosphate-binding gels have been used for years to treat hyperphosphataemia in patients with chronic renal failure. Unfortunately, very high doses (100 mg/kg per day) were needed to control hyperphosphataemia in some paediatric cases, and symptoms of aluminium-associated bone diseases were sometimes observed. Thus the use of these aluminium-containing pharmaceutical agents is now discouraged among children with chronic renal failure (Committee on Nutrition, American Academy of Pediatrics 1986).

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Ciba Foundation Symposium 169 - Aluminium in Biology and Medicine

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