By R. H. Quarles, R. G. Farrer, S. H. Yim (auth.), Bernhard H. J. Juurlink, Richard M. Devon, J. Ronald Doucette, Adil J. Nazarali, David J. Schreyer, Valerie M. K. Verge (eds.)
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Extra resources for Cell Biology and Pathology of Myelin: Evolving Biological Concepts and Therapeutic Approaches
25 Ilm. Reproduced with permission from Trapp et al.. 1989a. Figure 3. Electron micrographs of periaxonal regions of myelinated fibers from control (A,C), Quaking (B) and MAG-deficient (D) mice. In control fibers a 12-14 nm peri axonal space (A,C. arrowheads) separates a MAG-containing Schwann cell peri axonal membrane from the extracellular leaflet of the axolemma, and a Schwann cell cytoplasmic collar (A,C, arrows) separates the cytoplasmic leaflet of the periaxonal membrane and inner compect myelin lamellae.
Wl . V•••• 1 T. wg! • IIIOUS. human """'.. """'s. hU,",," cow rot . , .. y .. """' human . . n. ",NPGi' At I Alite, CLOY fi y. I. . . .... t. •• • 11 •• HRRLAGOF LEELR PF 218 c",", B Figure 1. Sequence alignment of MOG peptide sequences. Panel A: Predicted peptide sequences from rat, mouse, human, and bovine cDNAs (Genbank numbers M99485, U64572, U64564. and L21757. respectively) are aligned with sequence differences noted below the corresponding site in rat MOG. ). Two Cys residues (e) are indicated that form the disulfide linkage for MOG's single 19-Iike domain.
The endocytosis motif consists of a tyrosine residue which is flanked by amino acids that prefer a random coil conformation and/or that are polar or positively charged. Amino acids which meet these criteria are underlined. Reprinted from (80 et al. 1995). L-MAG S-MAG L-MAG -8 R R Amino acid sequence Table 1. Identification of tyrosine internalization signals in the cytoplasmic doman of L-MAG ... = DO = =- = ~ ~ = = DO w Myelin-Associated Glycoprotein 33 bers by receptor-mediated endocytosis. The loss of L-MAG from Quaking peri axonal membranes results from increased endocytosis of L-MAG and possibly a decrease in LMAG production (Eo et al.
Cell Biology and Pathology of Myelin: Evolving Biological Concepts and Therapeutic Approaches by R. H. Quarles, R. G. Farrer, S. H. Yim (auth.), Bernhard H. J. Juurlink, Richard M. Devon, J. Ronald Doucette, Adil J. Nazarali, David J. Schreyer, Valerie M. K. Verge (eds.)