Get Asymmetric dearomatization reactions PDF

By Shu-Li You

ISBN-10: 3527338519

ISBN-13: 9783527338511

ISBN-10: 3527698469

ISBN-13: 9783527698462

ISBN-10: 3527698477

ISBN-13: 9783527698479

ISBN-10: 3527698485

ISBN-13: 9783527698486

ISBN-10: 3527698493

ISBN-13: 9783527698493

The 1st finished account of the quickly becoming box of uneven dearomatization reactions with a spotlight on catalytic equipment.
It introduces the idea that of dearomatization and describes contemporary development in uneven response methods with assorted catalyst platforms, corresponding to organocatalysts, transition steel catalysts, and enzymes. Chapters on dearomatizations of electron-deficient fragrant jewelry, dearomatization reactions through transition metal-catalyzed cross-couplings in addition to dearomatization techniques within the synthesis of advanced average items also are incorporated.
Written via pioneers within the box, this can be a hugely worthy resource of data not just for pro artificial chemists in academia and but additionally for all these have an interest in uneven methodologies and natural synthesis ordinarily

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Their previously developed BINOLphosphate-catalyzed [15] reduction of ketimines [16] was extended to quinolines and the desired tetrahydroquinolines were isolated in good to excellent yields (75–95%). 1), the scope was found to be broad with aryl, heteroaryl, and alkyl groups being well tolerated at the 2-, 3-, and 4-positions of the quinoline core. 1 The most important features of this unprecedented organocatalytic reduction of a heteroaromatic compound are the low catalyst loading, mild conditions, and operational simplicity, which renders the protocol environmentally friendly alternative to conventional metal-catalyzed reductions.

18 Stereospecific lithiation/dearomatizing cyclization: synthesis of α-methyl kainic acid. O Ph2P H N 1. t-BuLi, HMPA 2. RX R 3. 19 Stereospecific lithiation/dearomatizing cyclization of N-(α-methylbenzyl) phosphinamides. 1 Chiral Bases in Dearomatizing Cyclizations The reactions described in the preceding section required a chiral enantioenriched precursor. In the course of their investigations, the Clayden group found that the requisite configurationally stable (at low temperature) enantioenriched organolithium intermediate can also be accessed using a chiral base.

Chem. , and Tomioka, K. (1998) J. Org. , 63, 9351; c) 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. , and Yamada, K. (2001) J. Org. , 66, 7051. , and Koga, K. , 34, 681. P. (1996) J. Org. , 61, 2258. -L. (1992) J. Org. , 57, 2768. P. H. (2002) Product class 4: Arene organometallic complexes of Chromium, Molybdenum, and Tungsten in Science of Synthesis, Thieme, vol. 2 (ed T. Imamoto), pp. P. (2010) Chem. Eur. P. (2011) Chem. , 47, 3739. W. (1998) Chem. Eur. , 4, 57. P. (1997) J. Am. Chem. , 119, 4773.

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Asymmetric dearomatization reactions by Shu-Li You


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